Identifying a type of toxic effectors exported by the type VII secretion system to enhance competitive fitness in <i>Streptococcus suis</i>.

ABSTRACT:

Background

Streptococcus suis poses a significant threat to both pig farming and public health, causing severe disease such as septicemia and meningitis. The type VII secretion system (T7SS) delivers toxic effectors to play a crucial role in interbacterial competition and is vital for the zoonotic pathogen S. suis to colonize host tonsils effectively.

Results

Here, we identified a type of hypothetical T7SS effector in S. suis, which appears to be fragmented toxins lacking the N-terminal YeeF domain, redesignated as MSE-ExTs. MSE (marker for searching effectors) is a conserved sequence at the N-termini of modular effectors showing a diverse range of toxicities targeting NAD +. Cognate WXG100-like and full-length EssC proteins contribute to activate the T7

SUBMITTER: Bai Q 

PROVIDER: S-EPMC12558993 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature