Intravenously administered iron oxide nanoparticles with different coatings reversibly perturb immune cells in peripheral blood without inducing toxicity in mice.

ABSTRACT:

Introduction

Iron oxide nanoparticle formulations are widely used in clinical applications and have recently been explored for hyperthermia therapy, cancer imaging and treatment. Here, we report the effects of intravenously injected pegylated or poly acrylic acid decorated iron oxide nanoparticles coated with hydroxyethyl starch (HES) on host immune system and organs. These particles were compared with sucrose coated iron oxide nanoparticle (Venofer^®) and the coating compound HES-both FDA approved agents-alongside non-iron oxide polystyrene nanoparticles coated with HES (micromer^®).

Methods

Toxicity analysis was performed in healthy female normal FVB/NJ mice 60 days after nanoparticle injection, with complete blood analysis conducted at multiple time-po

SUBMITTER: Korangath P 

PROVIDER: S-EPMC12558996 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature