Survival outcomes associated with antidepressant use in glioblastoma: a cohort study.

ABSTRACT:

Purpose

Glioblastoma is the most common primary brain malignancy and carries significant mortality. Preclinical studies have highlighted the efficacy of antidepressant therapy in inhibiting glioblastoma progression; however, real-world evidence remains conflicting. We sought to investigate the impact of different commonly utilized antidepressant therapies on survival in patients with glioblastoma.

Methods

In total, 1464 consecutive patients with glioblastoma treated at a single institution from 2008 to 2023 were included for analysis. Multivariate cox regression analysis with antidepressant usage modeled as a time varying covariate was used to assess the effect of antidepressants while controlling for a priori selected clinical variables with known relevance to survival.

SUBMITTER: Sun Y 

PROVIDER: S-EPMC12559032 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature