Kinetic and quantitative analysis of [¹⁸F]SMBT-1 PET imaging for monoamine oxidase B.

ABSTRACT:

Background and objective

In neuroinflammation, activated astrocytes, called reactive astrocytes, highly express monoamine oxidase B (MAO-B). [¹⁸F]SMBT-1 is a novel PET tracer developed for imaging neuroinflammation, with highly selective binding to MAO-B. The quantification method for [¹⁸F]SMBT-1 PET imaging has not been established, although some human studies using [¹⁸F]SMBT-1 PET imaging have already been conducted. In this study, we explored the most appropriate method for quantifying [¹⁸F]SMBT-1 PET.

Methods

Dynamic PET scanning of [¹⁸F]SMBT-1, accompanied by serial arterial blood sampling, was performed in healthy elderly subjects. With PET and blood data, the total distribution volumes (Vts) in the brain regions w

SUBMITTER: Hiraoka K 

PROVIDER: S-EPMC12559039 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature