Research on 3D-printed scaffolds with microstructure bio-inspired optimization for orbital bone defect repair.

ABSTRACT: Mechanical compatibility is a major challenge in designing orbital bone scaffolds, which involving material selection, structural design and fabrication processes. In this study, a novel impact model database containing essential components involved in tissue engineering repair of orbital fracture was established for finite element analysis (FEA). The mechanical compatibility between various pattern-designed scaffold and the orbital bone defect site was tested to raise the optimized square pattern filled scaffold for the subsequent study. Based on the optimized structure, 3D printed bone scaffolds with different β-TCP contents were fabricated. It was confirmed that the composite scaffold containing 30% β-TCP and 70% polycaprolactone (PCL@30TCP) demonstrated significantly enhanced hydrophil

SUBMITTER: Lv X 

PROVIDER: S-EPMC12559048 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature