Harmonization of quantitative liver function evaluation using gadoxetate disodium-enhanced magnetic resonance imaging.

ABSTRACT:

Objectives

This study aimed to develop a clinically applicable harmonization method for the hepatocellular uptake index (HUI), a quantitative liver function index, using gadoxetate disodium-enhanced (EOB)-MRI, to ensure consistency across diverse MR systems.

Materials and methods

This retrospective study, approved by our institutional review board, included consecutive patients who underwent three-dimensional gradient-echo T1-weighted EOB-MRI, HUI measurements, indocyanine green disappearance rate (ICG-PDR), and albumin-bilirubin linear predictor (ALBI-LP) between April 2011 and June 2024. Six different MR systems were used for HUI measurements. A harmonization method using ALBI-LP was developed and validated for estimating liver reserves corresponding to ICG-PDR through sta

SUBMITTER: Yoshizawa E 

PROVIDER: S-EPMC12559099 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature