Co-Expression of Mutant Tau and α-Synuclein in Neurons Promotes Tau Phosphorylation, Neuronal Loss, and Neuroinflammation in Mouse Brain.

ABSTRACT: Intracellular aggregation and accumulation of protein is a hallmark of neurodegenerative diseases. Tauopathy, which is caused by aggregated tau accumulation, is a group of neurodegenerative diseases, including frontotemporal dementia (FTD), Pick disease, and Alzheimer's disease. Similarly, synucleinopathy, which is caused by aggregated α-synuclein (α-syn) accumulation, includes Parkinson's disease and dementia with Lewy body (DLB). The interaction between tau and α-syn has been attracting attention because of similarities in symptoms and the co-existence of tau and α-syn in neural cells. Previous studies revealed that tau and α-syn promote their aggregation with each other. Additionally, other studies showed that α-syn promotes tau spreading in the mouse brain. In the present study, we inv

SUBMITTER: Yamamoto Y 

PROVIDER: S-EPMC12559100 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature