Exploring the Biological Connection Between Tau and PrP^C in Neuronal Cells: GSK3β as a Possible Key Player.

ABSTRACT: Cellular prion protein (PrP^C) and tau are highly expressed in the brain and overlap at the cellular level in neurons. Both proteins contribute directly to neurodegeneration processes in a misfolding state, although in their natural conformation, they play important roles in neurogenesis that could have a common link according to the recent literature. In this sense, it is well known that the proteinase-K resistant PrP^C isoform (PrP^Sc), the prion, is the causal agent of prionopathies. And misfolded tau, which is responsible for tauopathies, is considered "prion-like" because it displays similar behavior to prions in terms of self-aggregation and spreading properties. At the physiological level, PrP^C potentiates neuronal differentiation while tau i

SUBMITTER: Gavin R 

PROVIDER: S-EPMC12559108 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature