Interruption of the Gut Integrity Contributes to Early Accumulation of Amyloid-β in the Enteric Nervous System in Rats Supplemented with a High-Fat Diet.

ABSTRACT: Consumption of a high-fat diet (HFD) contributes to numerous chronic illnesses, including neurological disorders and gastrointestinal dysfunction. The study design included four groups, each consisting of six rats: the control group was fed regular chow, while groups 2 (HFD 2W), 3 (HFD 4W), and 4 (HFD 8W) were given a 60% HFD for 2, 4, and 8 weeks, respectively. A significant change in the latency to the platform in the water maze, a decrease in the percentage of successful cycles in the Y-maze, and a reduction in the percentage of time spent with the novel object were observed between the baseline and endpoint results in the HFD 4W and HFD 8W groups; notably, this was not the case in the control and HFD 2W groups. Consistent with the increased duration of HFD intake, marked damage to the

SUBMITTER: Gawish Z 

PROVIDER: S-EPMC12559146 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature