Progressively altered genes in colorectal carcinogenesis link oncogenesis immune cycle and tumor microenvironment.

ABSTRACT: The adenoma-adenocarcinoma pathway represents a crucial mechanism underlying the development of colorectal precancerous lesions, encompassing approximately 85%-90% of colorectal cancer (CRC). Elucidating the molecular mechanisms underlying colorectal cancer progression is of paramount importance for achieving early and accurate diagnosis as well as effective treatment. We collected peripheral blood mononuclear cells (PBMC) from healthy controls, adenoma patients, and adenocarcinoma patients, and performed transcriptomic profiling to characterize dynamic gene expression during carcinogenesis. Diagnostic potential was assessed using receiver operating characteristic (ROC) analysis, and a random-forest model was trained to classify disease status. The screening identified genes with consisten

SUBMITTER: Zhou B 

PROVIDER: S-EPMC12559207 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature