Development and validation of predictive model for emesis in cervical cancer patients receiving concurrent chemoradiotherapy based on multi-institutional retrospective study.

ABSTRACT: Chemotherapy-induced nausea and vomiting (CINV) remains a significant barrier to treatment adherence and quality of life in cervical cancer patients receiving chemoradiotherapy. No validated predictive models exist to assess CINV risk in this population. We aimed to develop and temporal validate a predictive model for CINV incidence in cervical cancer patients receiving concurrent chemoradiotherapy (CCRT). This multi-institutional, retrospective cohort study analyzed 921 patients who received CCRT with weekly cisplatin (40 mg/m²) between January 2016 and March 2024. Candidate predictors were selected through expert consultations and literature reviews. A multivariate logistic regression model was developed using training data, and the model with the highest receiver operating ch

SUBMITTER: Yoshida K 

PROVIDER: S-EPMC12559208 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature