Equivalence of the FCSRT and RAVLT to detect medial Temporal lobe atrophy and tauopathy.

ABSTRACT: In AD research, word-learning tests are often used interchangeably despite using distinct learning protocols. This study verified the equivalence of the Rey Auditory Learning Test (RAVLT) and Free and Cued Selective Reminding Test (FCSRT) when investigating medial temporal lobe (MTL) changes and AD-related tau pathology. We obtained the FCSRT and RAVLT immediate and delayed free recalls from 286 participants aged 51+. We segmented MTL regions to obtain the volume and tau-PET signal using the [¹⁸F]MK-6240 tracer. Tau-PET Braak stages and plasma p-tau₁₈₁, p-tau₂₁₇ and p-tau₂₃₁ quantifications were also acquired. Using partial correlations, we compared FCSRT to RAVLT as well as their ability to detect the cognitive status the AD biomarker results. F

SUBMITTER: Aumont E 

PROVIDER: S-EPMC12559241 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature