Impact of Collateral Vessels on Fontan Circulation: 0- to 1-Dimensional Fontan Circulation Model and Concept of Oxygen Supply and Consumption.

ABSTRACT:

Background

Patients with single ventricle often undergo the Fontan operation to alleviate cyanosis and reduce ventricle volume load. However, long-term outcomes are limited by complications and hemodynamic issues, including collateral vessels, leading to cyanosis and heart failure. Studies have demonstrated considerable blood flow through these collateral vessels; however, their hemodynamic impact on Fontan circulation remains inadequately explained from a theoretical perspective. This study aims to clarify the effects of dobutamine and vasodilators on Fontan circulation in the presence of aortopulmonary collaterals (APCs) and venovenous collaterals (VVCs).

Methods

A Fontan hemodynamic model incorporating VVC and APC was created. Scenarios were simulated by adjusting dobutam

SUBMITTER: Sughimoto K 

PROVIDER: S-EPMC12559264 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature