Identification of key biomarkers associated with necroptosis and immune infiltration in hepatitis B virus-related acute-on-chronic liver failure.

ABSTRACT: Hepatitis B virus-related acute-on-chronic liver failure (ACHBLF) is a severe condition associated with short-term mortality without liver transplantation. Substantial evidence indicates that necroptosis and immune infiltration play critical roles in ACHBLF development. Therefore, the identification of necroptosis-related biomarkers may be beneficial for prognostic evaluations and may shed light on potential therapeutic targets for ACHBLF. In this study, we used integrated bioinformatics analysis and machine learning algorithms to investigate the correlation between necroptosis and immune infiltration using peripheral blood mononuclear cells from ACHBLF patients. First, after GSE168048 and GSE248217 were obtained from the Gene Expression Omnibus (GEO) database, differentially expressed gen

SUBMITTER: Cao C 

PROVIDER: S-EPMC12559277 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature