Melatonin suppresses cancer cell proliferation, DNA repair and expression of the oncogene TRIP13.

ABSTRACT: Non-small cell lung cancer (NSCLC) continues to be a global health challenge, with limited treatment options and a high mortality rate. We recently found that lung cancer cells that express more genes that are typically restricted to the germline (germ cell cancer genes, GC genes) repair DNA double-strand breaks more rapidly, show higher rates of proliferation, and are more resistant to ionizing radiation, compared to cells that express fewer GC genes. Moreover, we found that the gene encoding TRIP13 (thyroid hormone receptor interactor 13) plays a significant role in this malignant phenotype. Here, we demonstrate that melatonin (MT), a hormone synthesized in the pineal gland, downregulates the expression of TRIP13, particularly in lung cancer cells with high expression of TRIP13. Moreover

SUBMITTER: Liu W 

PROVIDER: S-EPMC12559315 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature