Association of early VEGF trajectories with bronchopulmonary dysplasia severity in preterm infants.

ABSTRACT: To characterize longitudinal vascular endothelial growth factor (VEGF) trajectories and establish time-discriminative thresholds for bronchopulmonary dysplasia (BPD) severity stratification in extremely preterm neonates. Prospective observational cohort study with serial biomarker assessments. Tertiary neonatal intensive care unit in Suzhou, China (February 2022-January 2023). The cohort comprised 157 infants born at < 30 weeks' gestation with birth weights < 1250 g. After exclusions (n = 21), 136 infants completed the study protocol. BPD severity and weekly plasma VEGF levels (cord blood to postnatal day 28). Analyses included adjusted mixed-effects models for longitudinal trends and Receiver Operating Characteristic (ROC) curves with bootstrap 95% confidence intervals for discriminative

SUBMITTER: Lun Y 

PROVIDER: S-EPMC12559327 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature