Cucurbitacin B suppresses glioblastoma via the STAT3/ROS/endoplasmic reticulum stress pathway.

ABSTRACT: Cucurbitacin B (CuB), the tetracyclic triterpenoid compound belonging to cucurbitaceae family, demonstrates significant anticancer properties across various tumor types. However, its efficacy against glioblastoma (GBM), particularly in overcoming blood-brain barrier (BBB) and unique tumor microenvironment, remains a critical area of investigation. Our study reveals that CuB causes GBM cell apoptosis via STAT3/ROS/endoplasmic reticulum (ER) stress pathway. To enhance targeted delivery, we developed M@CuB-Lips, a novel formulation of CuB encapsulated in cancer cell membrane-coated liposomes. In vitro and in vivo experimental results verified targeted M@CuB-Lips delivery to brain tumor sites, demonstrating significant tumor inhibition and enhanced effector T-cell infiltration. These findings

SUBMITTER: Lv G 

PROVIDER: S-EPMC12559341 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature