TRIM17 promotes the progression of osteosarcoma by regulating PDK1 m6A modification-mediated AKT/mTOR pathway activation through ubiquitination of FTO.

ABSTRACT: Osteosarcoma is an extremely aggressive malignant tumor, which is quite common among children and has a high rate of disability and mortality. Tripartite Motif Containing 17 (TRIM17) is a member of the TRIM protein family and exhibits E3 ubiquitin ligase activity. In recent years, TRIM17 has been implicated in the development of various tumors, particularly in cancer cell clonability and survival potential and drug resistance; however, its regulatory mechanism in osteosarcoma progression remains poorly understood. We found that TRIM17 was significantly upregulated in osteosarcoma tissues and cells. Survival analysis revealed that TRIM17 was associated with poor prognosis in osteosarcoma patients. The higher the expression level of TRIM17, the worse the prognosis. Its expression was an inde

SUBMITTER: Liu W 

PROVIDER: S-EPMC12559362 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature