M7G-related gene signatures determine prognosis in triple-negative breast cancer.

ABSTRACT: Triple-negative breast cancer (TNBC), which lacks targeted treatment options, continues to pose a major clinical hurdle. This study investigated the molecular complexities of TNBC, with a focus on m7G modifications, the immune microenvironment, and their influence on patient prognosis. An integrated analysis of m7G-related genes facilitated the creation of a risk model based on differentially expressed m7G-related genes, which effectively stratified patients with TNBC into low- and high-risk groups, with the low-risk group demonstrating a marked survival advantage. Immune cell infiltration analysis revealed substantial differences between risk groups, suggesting a potential association between m7G-related risk and immune landscape modulation. Genomic profiling identified distinct mutationa

SUBMITTER: Li Y 

PROVIDER: S-EPMC12559392 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature