Impact of aging on gut-lung-adipose tissue interactions and lipid metabolism during influenza infection in mice.

ABSTRACT: Influenza remains a major threat to human health, especially for the elderly. Aging leads to substantial changes to lung function, gut microbiota, and white adipose tissue (WAT)-a key endocrine organ regulating energy balance and lipid metabolism. In the current study, we performed a multi-omics analysis to investigate how influenza impacts the gut-lung-adipose tissue axis differently with age at days 2, 4, 7, 14, and 28 post-infection (dpi). Compared to young-adult mice, aged mice experienced worse disease outcomes following infection, along with distinct WAT alterations, including impaired browning, heightened inflammation, and reduced innate immune cell recruitment. Age-related differences were also evidenced in infection-driven shifts in gut microbiota. Akkermansia levels rose only in

SUBMITTER: Bogard G 

PROVIDER: S-EPMC12559434 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature