Photoactivatable Synthetic Exosomes for RNA-Based Communication Between Artificial Cells and Living Cells.

ABSTRACT: Artificial cells are self-assembled microstructures engineered to replicate the functions of natural cells, such as the capacity to interact and communicate. Until now, communication between artificial and living cells has mainly been based on the exchange of small molecules. An important communication pathway in living systems, however, involves the exchange of bioactive molecules such as neurotransmitters and nucleic acids via their protected transport with vesicles or exosomes. Here, we describe a modular strategy to construct artificial cells able to regulate mammalian cell protein expression via vesicle-based RNA communication. These artificial cells are assembled from amylose-based complex coacervates stabilized by a terpolymer membrane, with polymersomes containing RNA sequestered i

SUBMITTER: Cook AB 

PROVIDER: S-EPMC12559445 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature