Reversible Mechanical Interlocking via Stimuli-Triggered Nonhomeomorphic Topology Transformation Enables Highly Efficient Rotaxane Synthesis.

ABSTRACT: Rotaxanes, as one of the most fundamental mechanically interlocked molecules (MIMs), have attracted considerable attention in many fields. However, a method that reconciles convenient, efficient, and "high-value-added" (such as reversibility, higher-order structures, and diverse topologies) synthesis of rotaxanes, remains challenging. Here, we report a threading-and-shrinking strategy to quantitatively prepare [2]rotaxane and bis[2]rotaxane (higher than 99% conversion and 92% isolated yield for [2]rotaxane; 96% conversion, 80% isolated yield for bis[2]rotaxane). The rotaxanes with a chair-like and an orthogonal geometry were synthesized in one pot by 365 nm UV light irradiation via shrinkage of macrocycle driven by reversible topology transformation between nonhomeomorphic structures, requ

SUBMITTER: Xiao C 

PROVIDER: S-EPMC12559457 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature