Circadian rhythm parameters differentiate euthymic, manic and depressive mood states in bipolar disorders - an explorative pilot study.

ABSTRACT:

Background

Bipolar disorders (BD) pose significant therapeutic health challenges due to recurrent and largely unpredictable depressive and (hypo)manic episodes. Traditional self-report methods for symptom monitoring are limited by their dependence on patient adherence which is frequently diminished during symptomatic phases. Circadian movement patterns, measured via actigraphy, have emerged as promising digital biomarkers for distinguishing mood states in BD. This study examined the utility of circadian rhythm parameters in differentiating euthymic, depressive, and (hypo)manic states.

Methods

This study analyzed data from 27 BD patients (mean age = 46 years, 16 female) monitored over 12 months as part of the BipoSense project. Wrist-worn accelerometers continuously recorded

SUBMITTER: Clemens J 

PROVIDER: S-EPMC12559485 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature