The correlation of DPM1 overexpression with immune infiltration and poor prognosis in hepatocellular carcinoma.

ABSTRACT:

Background

The DPM1 gene, crucial for glycosylation processes, has shown abnormal expression in various cancers, raising interest in its potential oncogenic role and as a biomarker in hepatocellular carcinoma (HCC).

Methods

Transcriptomic data were obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. DPM1 expression levels were compared between HCC tissues and adjacent normal tissues. Clinical correlations were assessed using statistical analyses, including survival analysis and multivariate Cox regression. Immune microenvironment profiling was conducted to evaluate associations between DPM1 expression and immune cell infiltration patterns.

Results

Elevated DPM1 levels were associated with advanced tumor stages (P < 0.001), higher

SUBMITTER: You L 

PROVIDER: S-EPMC12559490 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature