Quantifying DNA strand breaks from targeted alpha emitters ²²⁵Ac and ²²⁷Th via Geant4-DNA: implications for RBE and cell survival.

ABSTRACT:

Background

Targeted alpha therapy (TAT) utilizing high-LET alpha particles from radionuclides like ²²⁵Ac and ²²⁷Th shows promise in cancer treatment due to their ability to induce dense, localized DNA damage. This study uses the Geant4-DNA Monte Carlo toolkit to simulate DNA damage and evaluate the radiobiological effects of ²²⁵Ac and ²²⁷Th.

Results

The simulations revealed that both ²²⁵Ac and ²²⁷Th induce significant DNA damage, particularly complex double-strand breaks (DSBs), with ²²⁷Th producing slightly more clustered damage due to its longer decay chain and higher alpha energy. The study also found that both radionuclides exhibited elevated Relative Biological Effectiveness (RBE), especially f

SUBMITTER: Zolghadri S 

PROVIDER: S-EPMC12559532 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature