GNPNAT1 acts as a prognostic biomarker associated with immune infiltration in lung adenocarcinoma and promotes the proliferation and invasion of cancer cells.

ABSTRACT:

Background

Lung cancer persists as the foremost cause of cancer-related mortality worldwide, with lung adenocarcinoma (LUAD) representing the predominant histological subtype. Although GNPNAT1 has been implicated as a prognostic indicator in breast and prostate malignancies, its functional significance and mechanistic role in LUAD remain to be elucidated.

Methods

We performed comprehensive bioinformatic analyses to compare GNPNAT1 expression levels and prognostic impact in LUAD versus normal pulmonary tissues. Functional enrichment and single-cell transcriptomic analyses were employed to infer GNPNAT1-associated biological pathways. Immune cell infiltration was quantified using established deconvolution algorithms to assess correlations with GNPNAT1 expression. In vitro assa

SUBMITTER: Li Q 

PROVIDER: S-EPMC12559560 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature