Integrated WGCNA retrieval of T-cell exhaustion genes related to radiosensitivity in locally advanced cervical cancer and prediction of immunotherapy efficacy.

ABSTRACT: For more than two decades, concurrent chemoradiotherapy (CCRT) has been considered the standard treatment for locally advanced cervical cancer (LACC) and has achieved remarkable clinical results. Nevertheless, 30-40% of treated patients would appear recurrence within 5 years. Recently, Immunotherapy-based programs have been attempted for effective treatment of LACC, while T cell exhaustion greatly limits the application of immunotherapy in cancer radiotherapy (RT). This study aimed to comprehensively characterize the specific prognostic factors of radiosensitivity-related T cell exhaustion (rrTex) in LACC, and identify gene signatures that contribute to predict the efficacy of immunotherapy. LACC samples in several datasets were categorized into two groups (benefit vs. no benefit) accordin

SUBMITTER: Dong M 

PROVIDER: S-EPMC12559565 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature