A retrospective analysis exploring the association of pretreatment neutrophil-to-lymphocyte ratio and immune checkpoint inhibitor outcomes in patients with advanced NSCLC and liver metastases.

ABSTRACT:

Background

Liver metastases (LM) in advanced non-small-cell lung cancer (NSCLC) are associated with poor clinical outcomes. The tolerogenic immune microenvironment in the liver may contribute to inferior response to immune checkpoint inhibitors (ICIs). We hypothesized that the presence of LM may be associated with an expanded peripheral myeloid population, using the neutrophil-to-lymphocyte ratio (NLR) as a surrogate in patients treated with ICIs.

Objectives

We evaluated the impact of LM and NLR on clinical outcomes in patients with advanced NSCLC treated with ICIs.

Design

This was a retrospective analysis conducted at a single cancer center.

Methods

We reviewed the records of 324 patients with advanced NSCLC treated with programmed death ligand-1 (PD-L1) inhib

SUBMITTER: Makarem M 

PROVIDER: S-EPMC12559634 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature