Activated Peripheral CD8 + T Lymphocytes Inhibit the Proliferation of Hippocampal Neural Stem Cells via the IFN-γ/JAK/STAT Signaling Pathway.

ABSTRACT:

Background

The inhibition of hippocampal neurogenesis is associated with cognitive impairment in a variety of diseases, which are often accompanied by neuroinflammation. Our preliminary results revealed that the number of CD8 + T lymphocytes infiltrating the hippocampus of mice that underwent major abdominal surgery increased significantly and contributed to the inhibition of hippocampal neurogenesis and cognitive impairment. However, which stage of hippocampal neurogenesis is affected and the specific mechanisms involved remain unclear.

Methods

We isolated hippocampal neural stem cells (NSCs) and peripheral CD8 + T lymphocytes from C57BL/6 mice and then used a transwell coculture system to mimic the state in which peripheral CD8 + T lymphocytes infiltrated the parenchyma bu

SUBMITTER: Li X 

PROVIDER: S-EPMC12559668 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature