A peptide-based medical device for the selective removal of inflammatory factors from the blood of people with sepsis.

ABSTRACT:

Background

Sepsis is a complex life-threatening clinical condition associated with significant morbidity and mortality. It is usually triggered by an infection, the cellular response to which progresses, involving the innate immune system and leading to a cytokine storm that can provoke death.

Methods

The device is based on the peptide SET-M33, an antimicrobial molecule with strong antibacterial activity. The peptide was conjugated with a biocompatible agarose matrix via a covalent sulfonic bridge, then encapsulated in a device to insert in a circulation system. Here we describe a medical device that selectively and simultaneously remove the major triggers of the onset and progression of sepsis from the blood of sepsis patients. These include live bacteria and their componen

SUBMITTER: Cappello G 

PROVIDER: S-EPMC12559756 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature