Exploring Organ-Specific Extracellular Vesicles in Metabolic Improvements Following Bariatric Surgery in Youth With Obesity.

ABSTRACT:

Objective

Vertical sleeve gastrectomy (VSG) promotes significant metabolic improvements, though the underlying molecular mechanisms are not fully understood. Emerging evidence suggests that small extracellular vesicles (sEVs) contribute to metabolic improvements post VSG, such as improved fatty liver disease or adipose tissue function; however, it is unclear how different organ-specific sEVs interact with various metabolic parameters. The objective of this study is to establish the role of organ-specific sEVs in the metabolic improvements post VSG.

Methods

Demographic and anthropometric data, metabolic parameters, and sEV samples were collected pre VSG and 3-6 months post VSG in youth with obesity. sEV RNA was sequenced for bioinformatics analyses.

Results

A significa

SUBMITTER: Kim A 

PROVIDER: S-EPMC12559774 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature