CKD progression, kidney failure, and mortality among US patients with IgA nephropathy.

ABSTRACT:

Background and hypothesis

We assessed disease progression among patients with immunoglobulin A nephropathy (IgAN) and characterized factors associated with risk for adverse outcomes.

Methods

A retrospective longitudinal cohort (2000-2022) study of adults with biopsy-confirmed IgAN within Kaiser Permanente Southern California was performed. The outcome of interest was a composite of ≥50% estimated glomerular filtration rate (eGFR) decline, kidney failure, or mortality. Cox proportional hazards regression modeling was used to estimate hazard ratios (HR) for the eGFR decline/kidney failure with adjustment for potential confounders.

Results

Among 655 patients with primary IgAN (31% Asian/Pacific Islander, 3% Black, 40% Hispanic/Latino, 24% White), 234 (36%) reached the co

SUBMITTER: Sim JJ 

PROVIDER: S-EPMC12559788 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature