High-flux hemodialysis with polymethylmethacrylate membranes reduces soluble CD40L, a mediator of cardiovascular disease in uremia.

ABSTRACT:

Background and hypothesis

Major adverse cardiovascular events (MACE) are the main cause of mortality in hemodialysis (HD). Soluble CD40 ligand (sCD40L) binds to CD40 on endothelial cells (EC) and vascular smooth muscle cells (VSMC), playing a potential role in MACE. HD registries show a reduced mortality for MACE using the polymethylmethacrylate (PMMA) membrane. Study objectives were (i) to confirm the role of sCD40L as independent predictor and mediator of MACE and (ii) to evaluate the effect of PMMA on sCD40L-mediated vascular aging.

Methods

In 201 patients treated by high-flux HD, sCD40L levels were measured and correlated with MACE; 54/201 patients with sCD40L greater than or equal to the median value were randomized for 9 months in two crossover groups alternatively tre

SUBMITTER: Marengo M 

PROVIDER: S-EPMC12559792 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature