High measured GFR as a predictor of all-cause mortality and cardiovascular disease in a prospective non-diabetic population cohort.

ABSTRACT:

Background

High glomerular filtration rate (GFR) is generally regarded as beneficial but has been associated with cardiovascular disease (CVD) and all-cause mortality in epidemiological studies. However, these investigations may have been biased by the non-GFR determinants of estimated GFR (eGFR). We compared the risk of high baseline iohexol clearance [measured GFR (mGFR)] and eGFR based on creatinine or cystatin C in a prospective longitudinal population-based study of the Renal Iohexol Clearance Survey (RENIS) cohort.

Methods

The cohort consists of a representative sample of the general population of persons 50-64 years of age without baseline CVD, diabetes or kidney disease in the municipality of Tromsø, Norway. We investigated non-linear associations in general additive

SUBMITTER: Eriksen BO 

PROVIDER: S-EPMC12559795 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature