Degradable Magnesium Implants with Caerin 1.9-Polycaprolactone Coatings Provide Extended Antibacterial Resistance and Outstanding Biocompatibility.

ABSTRACT: Implant-associated infections and foreign body responses remain major challenges in orthopedic and biomedical implant applications. In this study, we report a novel strategy to enhance the antibacterial and biocompatibility properties of magnesium (Mg) alloy implants by applying a biodegradable polycaprolactone (PCL) coating embedded with the host-defense peptide, caerin 1.9 (F3). Three Mg-based specimens, including pure Mg, cold-extruded AZ31, and fully annealed AZ31 (3A), were evaluated following PCL-F3 surface modification. The PCL-F3 coatings demonstrated sustained antibacterial efficacy both in vitro and in vivo, effectively inhibiting methicillin-resistant Staphylococcus aureus (MRSA) for up to 168 h. Among the groups, the 3A-PCL-F3 condition exhibited the most notable perform

SUBMITTER: Liu X 

PROVIDER: S-EPMC12559799 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature