A NADH Oxidase Nanozyme Restores Redox Homeostasis to Ameliorate Multi-Organ Aging and Ischemic Cardiomyopathy.

ABSTRACT: Redox imbalance resulting from NAD⁺ [nicotinamide adenine dinucleotide (oxidized form)] depletion and NADH (reduced form of NAD⁺) accumulation is a conserved hallmark of both aging and myocardial infarction (MI), promoting cellular senescence and limiting the efficacy of regenerative therapies. Despite several NADH oxidase (NOX)-mimetic nanozymes having been reported, their therapeutic utility in aging and cardiovascular repair remains largely unexplored. Here, we present a vanadium-based nanozyme (MXene-TA) that mimics bacterial NOX activity, catalytically oxidizing NADH to restore NAD⁺ and directly fixing redox imbalance. In aged (24-month-old) mice, systemic MXene-TA administration restored NAD⁺/NADH homeostasis and reduced senescence markers

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12559800 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature