KDM5A, a H3K4me3 demethylase, regulates skin wound healing by promoting M2 macrophage polarization via suppression of Socs1.

ABSTRACT:

Introduction

The inflammatory phase is critical for successful wound healing, with macrophages playing a central role by polarizing into different functional phenotypes. KDM5A, a histone demethylase, can epigenetically suppress Socs1, a key negative regulator of immune responses. However, the specific roles and mechanisms of the KDM5A-Socs1 axis in macrophage polarization during cutaneous wound healing remain largely unknown. This study aims to elucidate the function of KDM5A in wound repair, focusing on its regulatory crosstalk with Socs1 in macrophages.

Methods

We established a murine wound model to systematically evaluate wound closure kinetics, collagen deposition, healing scores, macrophage polarization dynamics, and inflammatory cytokine profiles. An in vitro co

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12559803 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature