Effective control of the emerging PEDV G2-c variant with an inactivated autogenous vaccine.

ABSTRACT:

Background

Porcine epidemic diarrhea virus (PEDV) is one of the most significant pathogens threatening the swine industry, causing severe economic losses in China. PEDV exhibits a high mutation rate, which may compromise the protective efficacy of currently available commercial vaccines.

Results

This report describes a PED outbreak occurring from February to April 2025 in a southern Hunan swine farm, resulting in approximately 3,000 neonatal piglet deaths within 1 week of birth. We isolated a PEDV strain (XWF/2025) from infected piglet intestinal contents, which phylogenetic analysis classified within the G2-c subgroup. An inactivated autogenous vaccine using intestinal tissues from infected piglets was rapidly developed, evaluated and administered to all sows in the affecte

SUBMITTER: Xu H 

PROVIDER: S-EPMC12559854 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature