Consensus statement on the exploration of clinical translation and application of electron ultra-high dose rate FLASH radiotherapy.

ABSTRACT: Ultra-high dose rate FLASH Radiotherapy (FLASH-RT) has attracted wide attention because the well-known FLASH effect and the extremely short irradiation time. During FLASH-RT, high radiation doses and dose rate (usually thousands of times compared with conventional radiotherapy (CONV-RT)) are delivered to the tumor area. This novel irradiation technique shows a reduction of normal tissue injury (20-40%) in comparison to CONV-RT. Meanwhile, FLASH-RT maintaining comparable tumor killing effect as CONV-RT. With the progress of basic research on FLASH-RT in reducing radiation-induced injury to normal tissues, clinical trials of FLASH-RT have been carried out across the world. To date, there is no consensus in China focused on the exploration of clinical transformation and application of electro

SUBMITTER: Luo H 

PROVIDER: S-EPMC12559927 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature