Molecular Characteristics of Spontaneous Remission in Major Depressive Disorder: Changes in Serum Acetylcarnitine and Glycerophosphcholine Levels.

ABSTRACT:

Objective

Spontaneous remission may influence the outcome of clinical trials and evaluation of antidepressant efficacy, as it is associated with placebo effects and false remission rates. However, the characteristics of spontaneous remission and its biological mechanisms remain poorly understood. This study aimed to explore the metabolic signatures and underlying biological mechanisms of spontaneous remission using metabolomics.

Methods

This study conducted untargeted and targeted metabolomic analyses in a discovery cohort (n = 16) comprising patients with major depressive disorder (MDD) and those who were spontaneously remitted without medication. Findings were validated in an independent cohort (n = 185), comprising drug-treated patients and healthy controls.

Results

SUBMITTER: Lee S 

PROVIDER: S-EPMC12559932 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature