Clinical Outcomes and Treatment Intensification across Depression Subtypes in Patients Receiving Stepwise Pharmacotherapy over 24 Months.

ABSTRACT:

Objective

This study aimed to explore treatment outcomes and pharmacological treatment intensities across major depressive disorder (MDD) subtypes over a 24-month period in a naturalistic clinical setting.

Methods

A total of 1,079 MDD patients were classified into melancholic (n = 182; 16.9%), atypical (n = 68; 6.3%), and unspecified (n = 829; 76.8%) subtypes and followed in a longitudinal cohort study. Treatment intensity and outcomes, including 12-week and 12-month remission and 24-month relapse rates, were measured using the Hamilton Depression Rating Scale.

Results

There were no significant differences in remission or relapse rates across subtypes at 12 weeks, 12 months, or 24 months. However, melancholic and atypical subtypes received more intensive pharmacologic

SUBMITTER: Kim JM 

PROVIDER: S-EPMC12559947 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature