Synaptic communication within the microcircuits of pyramidal neurons and basket cells in the mouse prefrontal cortex.

ABSTRACT: Basket cells are inhibitory interneurons in cortical structures with the potential to efficiently control the activity of their postsynaptic partners. Although their contribution to higher order cognitive functions associated with the medial prefrontal cortex (mPFC) relies on the characteristics of their synaptic connections, the way that they are embedded into local circuits is still not fully uncovered. Here, we determined the synaptic properties of excitatory and inhibitory connections between pyramidal neurons (PNs), cholecystokinin-containing basket cells (CCKBCs) and parvalbumin-containing basket cells (PVBCs) in the mouse mPFC. By performing paired recordings, we revealed that PVBCs receive larger unitary excitatory postsynaptic currents from PNs with shorter latency and faster kine

SUBMITTER: Fekete Z 

PROVIDER: S-EPMC12559980 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature