Number and relative abundance of synaptic vesicles in functionally distinct priming states determine synaptic strength and short-term plasticity.

ABSTRACT: Heterogeneity in synaptic strength and short-term plasticity (STP) was characterized in post-hearing rat calyx of Held synapses at near-physiological external [Ca²⁺] under control conditions and after experimentally induced synaptic potentiation. Kinetic modelling was combined with non-negative tensor factorization (NTF) to separate changes in synaptic vesicle (SV) priming kinetics from those in SV fusion probability (p_{fu sion}). Heterogeneous synaptic strength and STP under control conditions can be fully accounted for by assuming a uniform p_fusion among calyx synapses yet profound synapse-to-synapse variation in the resting equilibrium of SVs in functionally distinct priming states. Although synaptic potentiation induced by either elevated resti

SUBMITTER: Lin KH 

PROVIDER: S-EPMC12559982 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature