The synaptic vesicle cluster as a controller of pre- and postsynaptic structure and function.

ABSTRACT: The synaptic vesicle cluster (SVC) is an essential component of chemical synapses, which provides neurotransmitter-loaded vesicles during synaptic activity, at the same time as also controlling the local concentrations of numerous exo- and endocytosis cofactors. In addition, the SVC hosts molecules that participate in other aspects of synaptic function, from cytoskeletal components to adhesion proteins, and affects the location and function of organelles such as mitochondria and the endoplasmic reticulum. We argue here that these features extend the functional involvement of the SVC in synapse formation, signalling and plasticity, as well as synapse stabilization and metabolism. We also propose that changes in the size of the SVC coalesce with changes in the postsynaptic compartment, suppo

SUBMITTER: Reshetniak S 

PROVIDER: S-EPMC12559990 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature