Benzilmonoximethiocarbohydrazide Schiff bases as multifunctional antimalarial and antioxidant scaffolds: synthesis, biological evaluation, and mechanistic insights.

ABSTRACT: A new series of benzilmonoximethiocarbohydrazide (HBMT) Schiff bases was synthesized and structurally characterized with high purity. Four derivatives-HBMT-3M4HB, HBMT-MA3, HBMT-MA6, and HBMT-MA7-were obtained in good yields and evaluated for multifunctional therapeutic potential. All compounds showed significant antimalarial activity against Plasmodium falciparum 3D7, with HBMT-3M4HB being the most potent (IC₅₀ = 1.24 μM), approaching chloroquine. Antioxidant assays revealed that HBMT-3M4HB also exhibited strong radical scavenging and ferric reducing power, surpassing its analogues. Cytotoxicity testing in MCF-7 breast cancer cells indicated selective activity (IC₅₀ = 21.6 μM) with reduced toxicity toward HEK-293 cells. Mechanistic assays suggested apoptosis i

SUBMITTER: Singh SK 

PROVIDER: S-EPMC12559995 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature