The winter is coming: seasonal variations in BDNF levels among older adults in a high-latitude region - a preliminary study.

ABSTRACT:

Objective

To evaluate seasonal changes in plasma Brain-Derived Neurotrophic Factor (BDNF) from the start to the end of winter and identify moderating factors.

Methods

An observational longitudinal study of 17 community-dwelling older adults (mean age 76.4 ± 5.6 years; 12 women) was conducted with assesments performed at the beginning and at the end of the winter, which included multi-frequency bioelectrical impedance analysis for body composition, standardized physical performance testing, cognitive and anxiety screening, and plasma BDNF quantification by enzyme-linked immunosorbent assay. Data were analyzed using hierarchical Bayesian mixed-effects models with time-by-covariate interaction terms; inference was based on posterior medians and 95% highest-density credible inte

SUBMITTER: Castillo-Aguilar M 

PROVIDER: S-EPMC12560003 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature