An AI-Powered Lifestyle Intervention vs Human Coaching in the Diabetes Prevention Program: A Randomized Clinical Trial.

ABSTRACT:

Importance

Prediabetes is common, yet evidence-based lifestyle interventions are underutilized.

Objective

To determine whether referral to an exclusively artificial intelligence (AI)-led lifestyle intervention based on the Diabetes Prevention Program (DPP) is noninferior to referral to a human-led DPP in achieving recommended thresholds for weight loss, hemoglobin A1c (HbA1c) reduction, and weekly physical activity among adults with prediabetes and overweight or obesity.

Design, setting, and participants

This phase 3, parallel-group, pragmatic, noninferiority randomized clinical trial was conducted from October 11, 2021, to December 16, 2024 (last follow-up) at 2 US clinical sites in Baltimore, Maryland, and Reading, Pennsylvania. Adults 18 years or older with prediab

SUBMITTER: Mathioudakis N 

PROVIDER: S-EPMC12560030 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature