Flat Plasmonic Biosensor with an On-Chip Metagrating-Integrated Laser.

ABSTRACT: Metasurfaces are emerging as a transformative platform in optics, offering compact and versatile alternatives to bulky traditional components. Here, we present a metasurface-enabled, on-chip surface plasmon resonance (SPR) biosensor that enables label-free biomolecular analysis in a miniaturized, chip-scale format. By integrating flat metaoptics together with semiconductor lasers, a collimated fan of light for angle-resolved SPR measurements can be emitted directly into a glass substrate, eliminating the need for conventional optics. As a proof of concept, we demonstrate a bulk refractive index sensitivity of 4.9 × 10^-6 RIU, along with multiplexed detection of low-molecular-weight microRNA with limits of detection of 0.1 nM via direct sensing and 0.02 nM with antibody amplificat

SUBMITTER: Strandberg E 

PROVIDER: S-EPMC12560135 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature