From electron spin to relaxivity: a multidisciplinary perspective on first-row transition metal-based MRI probes.

ABSTRACT: The electron spin is a key enabler of some of the most advanced current technologies. A prime example is the development of MRI contrast agents, where precisely engineered electron spin properties are utilized to enhance the capabilities of one of the most powerful diagnostic tools in the medical science. Clinically approved contrast agents are based on paramagnetic gadolinium(iii) complexes. However, to alleviate health and environmental concerns, as well as for specialized applications, alternatives are sought after. Due to their rich chemistry, abundance and low toxicity first-row paramagnetic transition metal ions are emerging as an appealing alternative. A large experimental effort is needed to engineer the new generation of contrast agents. The primary source of information comes fro

SUBMITTER: Salvadori E 

PROVIDER: S-EPMC12560143 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature