Task-based effective connectivity finds alterations in frontoparietal network in Duchenne muscular dystrophy.

ABSTRACT: Duchenne muscular dystrophy is a monogenic X-linked genetic disorder that is caused due to the absence of dystrophin. In addition to the skeletal and cardiac manifestations, challenges in executive function are pervasive and persistent, affecting a majority of young individuals with Duchenne muscular dystrophy. Executive function-related disability is linked to chronic stress, academic under-achievement and poor vocational attainment. Of the executive function domains, inhibitory control and working memory are disproportionately affected, and linked to academic under-achievement in Duchenne muscular dystrophy. Despite its consequential importance to the quality-of-life in affected individuals, the neural substrates underpinning working memory challenges are poorly understood in this diseas

SUBMITTER: Thangarajh M 

PROVIDER: S-EPMC12560160 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature